Answer: Generally, no. Effervescent delivery systems are used to enhance the bioavailability of certain drugs or supplements. Effervescence can occur in the stomach after ingestion, the esophagus, small intestines and colon. Most dietary supplements that use an effervescent delivery system do so by complexing the ingredient(s) with CO2. Typically, the supplement is dropped in a glass of water, allowed to effervesce and then swallowed. This form of delivery and ingestion offers no advantage over typical tablets, capsules or gel caps, especially for dietary supplements. Usually it is a marketing ploy to distinguish their product from the same thing that everyone else is selling. A popular example is an effervescent form of creatine. There is absolutely no advantage (or supporting data) to justify using this delivery system over pure creatine monohydrate (either powder or tablet).